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Hepatocyte growth factor binding → potentiated c-Met receptor activation c-Met tyrosine kinase signaling → dendritic arborization pathways Positive modulation → amplification of existing signal rather than independent agonism Hydrophobic modifications → membrane permeability and central access Increased spine density → documented in hippocampal culture Core Areas of Scientific Investigation Synaptogenesis Research: Dihexa is used to study dendritic spine density and synapse formation in hippocampal culture